Efficacy of Semaglutide and Other GLP-1 Agonists in Patients with Heart Failure With Preserved Ejection Fraction and Obesity: A Systemic Review and Meta-Analysis
- Design
- Meta-analysis · 2194 participants · Mixed outcome
- Match to healthy normal-weight adults aged 55–75
- Different population[Auto] Synthesis of studies conducted predominantly in people with obesity/overweight.
- Could weight loss explain it?
- Possibly[Auto] Participants had obesity and/or type 2 diabetes and the abstract does not separate direct drug effects from weight loss or glycaemic improvement.
- Study tier
- Study tier 3[Auto] Systematic review/meta-analysis including observational studies (auto-provisional).
- Assessment
- Version 1 · automatic, not yet reviewed by a person · Sep 13, 2026
Study facts come from the paper. Population match, weight-loss explanation and study tier are our judgments, made against the reference group of healthy normal-weight adults aged 55–75.
[Auto, unreviewed; last sentences of abstract] However, gastrointestinal adverse events leading to discontinuation were higher in the other GLP-1 agonists group (OR: 2.996, 95% CI: 1.683-5.331, P < 0.001). In HFpEF patients with obesity, GLP-1 agonists significantly improved symptoms, quality of life, physical function, and weight loss while reducing heart failure-related hospitalizations, though with increased gastrointestinal side effects.
01Findings
What the study reported
- Drugs
- Semaglutide
- Comparator
- placebo
- Primary outcome
- Not extracted
- Effect
- Not extracted
- 95% confidence interval
- Not extracted
- Follow-up
- Not stated
- Adverse events
- Not extracted
- Limitations
- Auto-classified from abstract only; effect estimates, adverse events and limitations not extracted. Requires manual review.
Who was studied
- Obesity status
- obesity/overweight present (all or most)
- Cvd status
- cardiovascular disease present in population (see abstract)
- Baseline condition
- heart failure with preserved ejection fraction
- Sample size
- 2194
Study quality details
- Study design
- Meta-analysis
- Sample size
- 2194
- Randomization
- n/a
- Blinding
- not stated
- Comparator
- placebo
- Follow up duration
- not stated
- Outcome type
- mixed
- Replication
- not assessed (auto)
- Consistency with other evidence
- not assessed (auto)
- Population applicability
- INDIRECT
- Statistical precision
- CI reported: 95% confidence interval (CI
- Risk of bias
- not assessed (auto)
- Funding conflicts
- unclear
- Peer review status
- yes
02Funding
Funding and conflicts
- Funding
- not reported in abstract
- Industry funded
- Unclear
- Manufacturer
- None identified
- Sponsor role
- not reported in abstract
- Author conflicts
- Disclosures: The authors have no conflicts of interest to report.
- Independent replication
- unknown
Funding is shown on every study and never used to score it.
04Source
The source, as retrieved
Abstract
Semaglutide, a novel drug, has shown potential benefits for heart failure with preserved ejection fraction (HFpEF) and obesity in early trials. This study aims to evaluate the efficacy and safety of semaglutide and other glucagon-like peptide-1 (GLP-1) agonists in HFpEF patients with obesity. A comprehensive electronic search was conducted on October 18, 2024, using PubMed, Scopus, Web of Science, Embase, and Cochrane. Eligible studies included those comparing semaglutide or other GLP-1 agonists to placebo in this patient population. Primary outcomes included changes in 6-minute walking distance, Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS), body weight, and secondary endpoints. Of 1116 studies, 4 met the inclusion criteria, comprising 2194 patients. GLP-1 agonists demonstrated a mean difference (MD) in 6-minute walking distance of 17.14 m [95% confidence interval (CI): 11.92-22.35, P < 0.001] and an MD in KCCQ-CSS of 7.3 (95% CI: 5.09-9.51, P < 0.001), indicating significant improvements in physical function and quality of life. Weight loss was substantial, with an MD of -7.19 kg (95% CI: -11.28 to -3.09, P = 0.001), alongside reduced inflammatory markers (C-reactive protein MD: -30.18, 95% CI: -38.16 to -22.2, P < 0.001). Hospitalizations or urgent care visits for heart failure were reduced (OR: 0.32, 95% CI: 0.15-0.66, P < 0.001). However, gastrointestinal adverse events leading to discontinuation were higher in the other GLP-1 agonists group (OR: 2.996, 95% CI: 1.683-5.331, P < 0.001). In HFpEF patients with obesity, GLP-1 agonists significantly improved symptoms, quality of life, physical function, and weight loss while reducing heart failure-related hospitalizations, though with increased gastrointestinal side effects.
Where this record came from
| Source | Retrieved | Identifier |
|---|---|---|
| pubmed | Sep 13, 2026 | 40243299 first ingestion |