Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging
- Status
- CompletedResults none
- Why it is watched
- non-weight indication: cardiovascular
- Who it enrolls
- age 50 Years to no upper limit; BMI ≥30 required; conditions: Type II Diabetes
- Interventions
- GLP-1 agonists; Cardiac MRI; Follow up by phone
- Conditions
- Type II Diabetes
- Phase and size
- NA · 42 participants
- Dates
- Start 2018-04-16
Primary completion 2023-06-06 - Sponsor
- Centre Hospitalier Universitaire Dijon (Other)
- Last checked
- Sep 13, 2026
01Endpoints
What the trial will measure
- Change from Baseline Concentration of intramyocardial triglycerides at 6 monthsMonth 6
02Eligibility
Who can take part
Inclusion Criteria: * Patient who has given his consent * Adult patient over 50 years of age Type II diabetic treated without modification of the antidiabetic treatment during the previous 3 months * HbA1c ≥ 7%. * Patient for whom a decision to start a GLP-1 agonist treatment has been made (Liraglutide, Semaglutide, Dulaglutide). * At least one risk factor from among: * Treated hypertension, * treated dyslipidemia, * History of obesity (BMI\>30 kg/m2) * Active smoking (from 1 cigarette per day) or smoking cessation for less than 3 years, * Coronary heredity (myocardial infarction or sudden death before age 55 in father/brother, myocardial infarction or sudden death before age 65 in mother/sister) Exclusion Criteria: \- Protected adult Patient not affiliated to a national health insurance scheme Pregnant or breastfeeding woman Women who intend to become pregnant or of childbearing age and do not use adequate contraceptive methods. Antidiabetic treatment of the incretin family (DPP4 inhibitor except sitagliptin) Severe renal failure (clearance \<30ml/min according to Cockroft due to gadolinium injection) Claustrophobia / contraindication to MRI (compatible non-MRI implanted metallic material) History of hypersensitivity to gadoteric acid or gadolinium-based contrast agents and meglumine Hypersensitivity to Liraglutide, Semaglutide, Dulaglutide or any of the excipients History or presence of pancreatitis (acute or chronic) Chronic inflammatory bowel disease Diabetic gastroparesis Dysthyroidism
03Change log
Registry changes
No changes recorded since the trial was added.