Semaglutide for Helping Opioid Recovery
- Status
- RecruitingResults none
- Why it is watched
- non-weight indication: addiction
- Who it enrolls
- age 18 Years to no upper limit; no BMI minimum stated; non-obese participants included; conditions: Opioid Use Disorder
- Interventions
- Semaglutide; Placebo
- Conditions
- Opioid Use Disorder
- Phase and size
- Phase 2 · 46 participants
- Dates
- Start 2025-06-02
Primary completion 2026-08-31 - Sponsor
- Brigham and Women's Hospital (Other)
- Last checked
- Sep 13, 2026
01Endpoints
What the trial will measure
- Cue-induced Cravings for OpioidsBaseline, 6 weeks, and 13 weeks after baseline visit
- Relapse to Illicit Opioid UseWeekly from baseline to end of study at 14 weeks
02Eligibility
Who can take part
Inclusion Criteria: * English speaking adults aged 18 and above * DSM-5 diagnosis of opioid use disorder, severe * Initiated sublingual buprenorphine (SL-BUP) treatment within 60 days of enrollment * Attained stable dosing of SL-BUP of 16mg or greater for 30 days prior to enrollment * Anticipating continuation of SL-BUP for the duration of the trial * Agreeable with bringing SL-BUP prescription to visits to allow study team to conduct a dose count * Willing to grant study team permission to communicate about SL-BUP treatment with community prescriber via completion of 42 CFR release Individuals with any of the following will be excluded: * DSM-5 diagnosis of any current substance use disorder excluding opioid, cannabis or tobacco * Active psychosis, active suicidality or homicidality or any psychiatric condition that impair ability to provide informed consent * Any current or lifetime diagnosis of eating disorders * BMI\<25mg/kg2 * Current or lifetime diagnosis of Type 1 or Type 2 diabetes * Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 * Use of any GLP-1 agonist medications in the prior 3 months * Anticipating receipt of any GLP-1 agonist medications during the trial * History of angina pectoris, coronary heart disease, congestive heart failure, inflammatory bowel disease, chronic obstructive pulmonary disease, bariatric surgery, idiopathic pancreatitis, diabetic gastroparesis * Liver function test greater than 3 times upper normal limit * Renal impairment as indicated by eGFR of \<60 * History of hypersensitivity or allergy to semaglutide * Pregnant or breastfeeding * Anticipated to participate in a concurrent drug trial * Any other reason or clinical condition that the investigators judge may interfere with study participation and/or be unsafe for a participant
03Change log
Registry changes
No changes recorded since the trial was added.