Glycemic Outcomes Associated With GLP-1 Receptor Agonist Shortages in Type 2 Diabetes
- Design
- Retrospective cohort
- Drugs
- Semaglutide, Dulaglutide
- Assessment
- Facts extracted automatically · reviewed by Carrie Schluter, Nov 5, 2026 · added Oct 18, 2026
This study was added automatically, and its details were extracted by machine rather than read off the paper by a person. Carrie Schluter has reviewed the record, but that review did not re-extract those details, so the collection still publishes no population match, weight-loss explanation, study tier, findings, population or funding details for it: a check of automatically extracted details found too many errors to show them as fact. The abstract below is the source as retrieved.
01Source
The source, as retrieved
Abstract
[INTRODUCTION] Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are integral in managing type 2 diabetes mellitus (T2DM) due to glycemic control, weight loss, and cardio-renal benefits. National shortages beginning in 2022 limited access to these medications. This study assessed the effect of GLP-1 RA shortages on hemoglobin A1c (HbA1c) and other outcomes. [METHODS] We conducted a retrospective pre-post cohort study of patients with T2DM prescribed dulaglutide or semaglutide before March 2022 at Cleveland Clinic Akron General. The primary outcome was HbA1c change from preshortage to shortage periods. Secondary outcomes included prevalence of patients affected, weight change, and provider responses. [RESULTS] Of 177 patients, 55 (31.1%) were affected. Median HbA1c increased by+0.4% (P<0.001), while weight decreased by -4.33 kg (95% CI -6.50 to -2.16, P<0.001). [CONCLUSION] The GLP-1 RA shortage adversely affected glycemic control, underscoring the need for improved management strategies during supply disruptions.
Where this record came from
| Source | Retrieved | Identifier |
|---|---|---|
| pubmed | Oct 18, 2026 | 42871656 first ingestion |
| pubmed | Oct 25, 2026 | 42871656 duplicate matched on doi |
| owner-review | Nov 6, 2026 | reviewed_by set to Carrie Schluter (2026-11-05) on the owner's own confirmation. The assessment is unchanged and still the auto-classifier's, so its extracted values stay withheld under the 2026-10-18 decision. |