Research of Intensive Metabolic Intervention Before Pregnancy in PCOS
- Status
- UnknownResults none
- Why it is watched
- non-weight indication: endocrine, other_emerging
- Who it enrolls
- age 18 Years to 40 Years; female; no BMI minimum stated; conditions: PCOS; Impaired Glucose Tolerance
- Interventions
- Acarbose 100 MG; Exenatide; Orlistat; Metformin
- Conditions
- PCOS; Impaired Glucose Tolerance
- Phase and size
- Phase 4 · 160 participants
- Dates
- Start 2018-01-01
Primary completion 2018-12-31 - Sponsor
- RenJi Hospital (Other)
- Last checked
- Sep 13, 2026
01Endpoints
What the trial will measure
- Improvement of pregnant rate after intensive metabolic interventionup to 24 weeks
02Eligibility
Who can take part
Inclusion Criteria: * PCOS women at Childbearing Age * PCOS: Clinical hyperandrogenism and/or hyperandrogenemia, menstrual dysfunction (oligomenorrhea or amenorrhea) and exclusion of other known disorders. PCOS will be diagnosed using the 2003 Rotterdam criteria. Exclusion Criteria: * Past or present history of a medical disorder or medication known to affect body composition, insulin secretion and sensitivity, or the growth hormone (GH)-insulin-like growth factor 1 (IGF1) axis (eg steroid hormone or thyroid replacement). * History of current or past pregnancy * Hormonal contraceptive or metformin use within 3 months of enrollment * Nonclassical congenital adrenal hyperplasia
03Change log
Registry changes
No changes recorded since the trial was added.